Last week was tough for NFL picks with a number of underdogs prevailing, however we have been cautious with most of the favorites and ended up trying sturdy against the unfold. Now it is time to get again on observe straight up.

The excellent news is Week 6 brings two fewer video games on the schedule with 4 groups (Bills, Bears, Colts and Raiders) on bye weeks. So that is rather less to get unsuitable, but additionally a little much less to get proper.

MORE: Get the newest NFL odds at Sportsbook Review

Here’s taking our photographs, navigating by means of a couple of extra huge numbers and a number of other extra toss-up video games.

Week 6 NFL picks against the unfold

  • Game of the Week: San Francisco 49ers at Los Angeles Rams (-3, -115)

Sunday, 4:05 p.m. ET, Fox

The Rams are coming off a mini-bye after their Thursday night time recreation in Week 5, and the 49ers have a brief week turnaround on the street. The Rams are battling by means of a uncommon two-game shedding streak with Sean McVay, and they need to clear up a number of their points defensively whereas additionally discovering methods to be extra dynamic and balanced offensively. This can be a great duel between McVay and Kyle Shanahan, however the slight benefit at dwelling goes to at least one JG (Jared Goff) over the different (Jimmy Garoppolo).

Pick: Rams win 27-23 and canopy the unfold.

  • Game of the Midweek: New York Giants at New England Patriots (-17, -101)

Thursday, 8:20 p.m. ET, Fox, NFL Network, Amazon Prime Video

The Giants can be with out Saquon Barkley, Evan Engram and Sterling ShTheir remaining matchups against the Patriots’ protection aren’t good, and New York can be depending on largely chunk performs with Barkley to maneuver the ball. Tom Brady, in the meantime, can go to work against one other terrible secondary and put Jones in an uncomfortable catch-up place.

Pick: Patriots win 31-10 and canopy the unfold.

  • Upset of the Week: Philadelphia Eagles (+2 1/2, +110) over Minnesota Vikings

Sunday, 1 p.m. ET, Fox

The Vikings virtually blew an enormous lead however have been capable of win in Philadelphia final season. The Eagles will return the favor in Minneapolis. Both groups can cease the run, so it comes right down to which quarterback, Carson Wentz or Kirk Cousins, can distribute the ball beneath some warmth with out committing turnovers. Cousins will hit on some huge performs against the Eagles’ secondary, however Wentz can be just a little extra versatile as the Eagles play the higher ball-control recreation.

Pick: Eagles win 24-23.

  • Lock of the Week: Baltimore Ravens (-11, -107) over Cincinnati Bengals

Sunday, 1 p.m. ET, CBS

The Ravens are a run-first workforce with Lamar Jackson, Mark Ingram and their complementary backs. Their passing recreation is off, and rookie large receiver Marquise Brown is hurting. They will not get cute right here; they as a substitute will simply pound away against a Bengals protection that may’t cease something on the floor. Cincinnati, in the meantime, is making an attempt to maintain issues along with the offensive firepower they’ve left, however there is not any motive to suppose they may hold a division street recreation shut.

Pick: Ravens win 33-16 and canopy the unfold.

  • Carolina Panthers (-2, -105) at Tampa Bay Buccaneers

Sunday, 9:30 a.m. ET, NFL Network

The Panthers have gained three consecutive video games since Cam Newton struggled against the Bucs at dwelling in Week 2. Kyle Allen has performed OK, however he’s being buoyed by the working of Christian McCaffrey and the protection, two issues that did not work for Carolina in its first assembly with Tampa Bay. Nobody is aware of what the Bucs will get from Jameis Winston, and their pass-happy offense (and improved protection) is getting more durable to determine, too. The Panthers are the extra identified amount on a impartial area, and that is the place the belief ought to lie.

Pick: Panthers win 23-20 and canopy the unfold.

  • Houston Texans at Kansas City Chiefs (-5, -101)

Sunday, 1 p.m. ET, CBS

The Chiefs are not undefeated, and their offense cooled down final week due to the mixture of a banged-up Patrick Mahomes, a out of the blue shaky offensive line and no dedication to the working recreation. Mahomes, nonetheless, will get revved again up for a shootout with 2017 first-round draft mate Deshaun Watson, understanding he’ll seemingly get a big-play reinforcement in Tyreek Hill. Watson and Mahomes will take turns lighting it up, however the Chiefs can be higher positioned to drag away in the fourth quarter.

Pick: Chiefs win 34-27 and canopy the unfold.

Sunday, 1 p.m. ET, CBS

One can anticipate this recreation to function a number of Saints followers who made the comparatively quick 8-hour drive straight down I-10 to attempt to assist their workforce get to 4-Zero with Teddy Bridgewater beginning for Drew Brees. Bridgewater additionally may have some native assist again in his dwelling state, balancing out the magic that comes with Gardner Minshew taking part in in Jacksonville. Look for the Saints to get it finished, per normal with loads of Alvin Kamara and Michael Thomas and extra swarming protection to enhance them.

Pick: Saints win 26-20 and canopy the unfold.

  • Seattle Seahawks at Cleveland Browns (PK)

Sunday, 1 p.m. ET, Fox

Russell Wilson is a street warrior and is taking part in lights out, largely avoiding huge sacks in addition to turnovers. The Seahawks can also keep dedicated to the run on this recreation to maintain stress off the QB. Their protection will quit its share of massive cross performs to Baker Mayfield, but it surely can also disrupt the Browns’ offense in key conditions with Jadeveon Clowney. It can be more durable for Myles Garrett to throw off Wilson.

Pick: Seahawks win 24-20.

Sunday, 1 p.m. ET, Fox

The Redskins can be fired as much as ship their first win of the season for interim coach Bill Callahan. At the similar time, the Dolphins will come out flying after their bye week understanding that is their probability to crack the goose egg, too. Washington nonetheless has superior expertise, and if the guests shield the ball with extra dedication to the run, they will win a low-scoring recreation by a area aim.

Pick: Redskins win 19-16 however fail to cowl the unfold.

Sunday, 4:05 p.m. ET, Fox

The Falcons are in a foul state with Dan Quinn’s protection, however on this recreation, all the arduous work Matt Ryan is doing will repay. The QB will get to throw to Julio Jones with no worries about Patrick Peterson, who’s serving the last recreation of his six-week suspension. The Cardinals have been a spread-it-out offense, and Kyler Murray’s working may cause points, however they do not have a big-play offense. Their taking part in quick will solely assist the Falcons’ passing recreation put up digits.

Pick: Falcons win 31-27.

  • Dallas Cowboys (-7, +110) at New York Jets

Sunday, 4:25 p.m. ET, CBS

The Cowboys noticed their degree of competitors enhance over the final two weekrs, and so they weren’t as much as the job against the Saints or the Packers. But this may be their get-well recreation against a large number of a protection and restricted offense. Dak Prescott will break out of his hunch with a clear passing recreation, and Ezekiel Elliott lastly will feed off a excessive quantity of touches. Le’Veon Bell is the solely participant the Jets can get going on this recreation, however he will not present sufficient to make a lot of a distinction, even with a wholesome Sam Darnold.

Pick: Cowboys win 38-13 and canopy the unfold.

Sunday, 4:25 p.m. ET, CBS

The Titans are 2-1 on the street and 0-2 at dwelling. They are the extra proficient defensive workforce with the higher probability for working success with Derrick Henry. Joe Flacco has the higher weapons total, but it surely’s a wash between him and Marcus Mariota when it comes to mediocre QB play. Go with Tennessee off a foul loss vs. Denver off an unsightly win.

Pick: Titans win 23-20.

Sunday, 8:20 p.m. ET, NBC

The Steelers may want to start out undrafted rookie Devlin Hodges after seeing Mason Rudolph go down with a scary concussion. One can anticipate the Steelers, then, to go run-heavy with James Conner and the associated Jaylen Samuels wrinkles to assault the Chargers’ defensive weak spot. The problem can be when the Chargers transfer the ball and end drives, which they did not do against the Broncos, and ultimately pressure Hodges (or Rudolph) to throw extra against their edge rush and secondary.

Pick: Chargers win 24-20 however fail to cowl the unfold.

Monday, 8:15 p.m. ET, ESPN

The Packers are featured in a prime-time recreation for the third time this season, including a Monday night time to their two Thursday night time appearances. They’ll fare higher than they did against the Eagles with the probability to go 3-Zero in the NFC North and begin pulling away in the division. This will seemingly flip right into a recreation of Aaron Rodgers and Matthew Stafford buying and selling cross performs throughout the area, however the Packers’ improved protection is just a little higher outfitted than the Lions’ unit to counter.

Pick: Packers win 30-23 and canopy the unfold.

Stats of the Week:
Week 5 file straight up: 6-8
Week 5 file against the unfold: 9-4
Season file straight up: 51-25
Season file against the unfold: 43-29
Upsets of the Week: 4-1
Locks of the Week: 3-2

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